AB0636 ASYMPTOMATIC HYPERURICEMIA IN INFLAMMATORY RHEUMATIC DISEASES

Background: Uric acid (UA) is well-known biomarker of cardiovascular risk and inflammation. However, the data about interrelations between asymptomatic hyperuricemia (AHU) rheumatic diseases (RD) are limited contradictory [1]. Objectives: to identify occurrence AHU in pts with different RD evaluate clinical features RD. Methods: The study included from 822 involved Saint-Petersburg Register Pts period 01jan2000 01apr2020. was defined as serum level uric that exceeded 360 μmol/l without signs gouty arthritis. secondary reasons (an oncologic diseases, late stages chronic kidney disease, ets), inflammatory another than were excluded study. Patient’s demographical characteristics, duration AHU, UA, activity RD, ESR, CRP, urate-lowering therapy (ULT) analyzed. approved by local ethic committee. Statistics performed SPSS17. Results: Characteristics Patients present Table 1. 3.4±3.4 [0.08-18] years, mean follow-up 2.7±4.0 number visits during 3,2 [min 1; max 7], ESR 26.0±14.1 mm / h, CRP 19.6±21.0 mg/l. Rheumatic hyperuricemia. Age, years (Mean±SD) Male, %** Serum Normalization UA follow-up, n (%) n=822 56.7±14.5 40.27 493.3±98.5 242 (29.44) ## RA, n=329 64.2±12.1 3.74 504.8±107.5 # 99 (30.09) PsA, n= 149 56.6±12.9 53.69 531.5±94.9 32 (21.48) SpA, 107 45.6±15.1* 33.43 520.8±86.5 18 (16.82) SLE, n=137 50.3±14.1* 20.44 451.6±91.4 57 (41.61) SSc, 61.0±12.4 22.81 456.2±99.5 20 (35.09) SD, 43 62.0±10.7 16.28 442.4±107.5 16 (37.21) – disease; RA –– rheumatoid arthritis; PsA psoriatic SpA spondyloarthritis; SLE systemic lupus erythematosus; SSc sclerosis; SD Sjogren’s * p<0.001 for differences SD; ** p < 0.01 all intergroup differences; SD. Were revealed (Spearmen’s R=0.1, p=0.01), R =0.12, p=0.001). male 507.0 [361-940], female 450.0 [361-1010] μmol /l (p<0.0001), elevated anti-nuclear factor (ANF) 429 [361-940] normal 494 [361-973] (p<0.0001). In high low 490 454 [363-1010]) respectively, higher found any compared same (p<0.0001 differences). 243 (29.6 %) pts, lack normalization 434 (52.8 cases, = 677, ULT received 219 (26.6 pts. registered (1.9 Conclusion: normalize less often patients compered SLA, analyzed disease activity. References: [1]K.Bosmansky, M. Ondrasik. Ter Arkh.1987;59(4):22-5. Disclosure Interests: None declared.